Claudins constitute integral membrane proteins responsible for solute and electrolyte permeability of the tight junction that serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets.
Tight junctions also play a critical role in maintaining cell polarity and signal transductions.
Claudin-9 creates charge specific channels in the paracellular space, plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity, is required to preserve sensory cells in the hearing organ because claudin-9-defective tight junctions fail to shield the basolateral side of hair cells from the K+-rich endolymph.
Its ion barrier function is essential in the cochlea, but appears to be dispensable in other organs.
Is one of the entry cofactors for hepatitis C virus; it enables HCV entry into target cells just as efficiently as CLDN1.
特徴
This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus.
The protein has a calculated MW of 27.9 kDa.
The protein migrates as 23-24 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：100ug
Source：Human Claudin-9, His,Twin-Strep Tag (CL9-H5586) is expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Val 217 (Accession # O95484-1).
