Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family.
TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.
The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer.
Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer.
Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
特徴
This protein carries a mouse IgG2a Fc tag at the N-terminus.
The protein has a calculated MW of 42.5 kDa.
The protein migrates as 47-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus / Rhesus macaque OX40 Ligand, Mouse IgG2a Fc Tag (OXL-R5259) is expressed from human 293 cells (HEK293). It contains AA Gln 51 - Leu 183 (Accession # F7FL80-1). In the region Gln 51 - Leu 183, the AA sequence of Cynomolgus and Rhesus macaque OX40 Ligand are homologus.
