the inhibitory KIR surface receptors possessing three extracellular immunoglobin (Ig) domains (3D) and only one inhibitory motif within the long cytoplasmic domain (L) due to a premature stop codon.
Moreover, exon 6 of KIR3DL3 encoding the stem part of the receptor is also absent, which differs from other inhibitory KIRs.
Understanding the function of KIR3DL3 is further complicated by the unknown identity of the specific ligand, but its importance is highlighted by its presence in all human KIR haplotypes with120 distinct polymorphic alleles of the coding sequence [
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 58.7 kDa.
The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human KIR3DL3, Fc Tag (KI3-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Leu 322 (Accession # Q8N743-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Gln 26 - Leu 322
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q8N743-1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
