Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1.
ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 15.9 kDa.
The protein migrates as 24-26 kDa and 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Rat ICOS (C137S, C138S), His Tag (ICS-R52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Pro 145 (C137S,C138S) (Accession # Q9R1T7-1 (C137S, C138S)).
