Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1.
ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.6 kDa.
The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse ICOS (C137S, C138S) Protein, Fc Tag (ICS-M5259) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Leu 144 (Accession # Q9WVS0-1 (C137S, C138S)).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Glu 21 - Leu 144
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9WVS0-1 (C137S, C138S)
Protein ID：NP_059508.2 (C137S,C138S)
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
