Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily.
GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.
GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 41.4 kDa.
The protein migrates as 46-49 kDa and 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human GITR Protein, Mouse IgG2a Fc Tag (GIR-H525a) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).
Species Reactivity：Human
Host：HEK293
Tag：C-mFc(mIgG2a)
Exp Region：Gln 26 - Glu 161
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9Y5U5-1
Protein ID：NP_004186.1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
