Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily.
GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.
GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 41.0 kDa.
The protein migrates as 45-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human GITR, Fc Tag (GIR-H5254) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Gln 26 - Glu 161
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9Y5U5-1
Protein ID：NP_004186.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
