Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family.
TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS).
TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation.
TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells.
TNFSF18 also mediates activation of NF-kappa-B.
特徴
This protein carries an Avi tag (Avitag) at the N-terminus, followed by a human IgG1 Fc tag.
The protein has a calculated MW of 43.5 kDa.
The protein migrates as 45-53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human GITR Ligand, Avitag,Fc Tag (GIL-H82F8) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1).
Species Reactivity：Human
Host：HEK293
Tag：N-Avi & N-Fc
Exp Region：Gln 50 - Ser 177
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：AAH69319.1
Protein ID：NP_005083.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
