FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer.
Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk.
FCGRT possible role in transfer of immunoglobulin G from mother to fetus.
Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
特徴
Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag, produced by co-expression of FCGRT and B2M, has a calculated MW of 34.1 kDa (FCGRT) and 11.6 kDa (B2M).
Subunit FCGRT is fused with a polyhistidine tag at the C-terminus , followed by an Avi tag (Avitag) and subunit Beta-2 microglobulin (B2M) contains no tag at the C-terminus.
The reducing (R) protein migrates as 35-40 kDa (FCGRT) and 13 kDa (B2M) respectively due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag, is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # Q8SPV9-1 (FCGRT) & Q8SPW0-1 (B2M)). In the region Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M), the AA sequence of Cynomolgus and Rhesus macaque FcRn (FCGRT&B2M) are homologus.
Species Reactivity：Cynomolgus / Rhesus macaque
Host：HEK293
Tag：C-10×His & C-Avi | Native
Exp Region：Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
