FcgR4(Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma .
Also acts as a receptor for the Fc region of immunoglobulin epsilon .
Binds with intermediate affinity to both IgG2a and IgG2b .
Does not display binding to IgG1 or IgG3.
Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a.
Binds with low affinity to both the a and b allotypes of IgE.
Has also been shown to bind to IgE allotype a only but not to allotype b.
Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 22.8 kDa.
The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse CD16-2, His Tag (FC4-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Gln 203 (Accession # A0A0B4J1G0-1).
