Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family.
TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS).
TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation.
TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells.
TNFSF18 also mediates activation of NF-kappa-B.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 41.5 kDa.
The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human GITR Ligand, Fc Tag (GIL-H526a) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1).
