83-3873-76　Cynomolgus Fc gamma RIIB / CD32b Protein, His Tag （MALS ＆ SPR verified） 50ug　CDB-C5224-50ug

特徴

• 背景
• Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses.
• Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
• There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B).
• CD32 is a low affinity receptor for IgG.
• Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2.
• CD32B is expressed on B cells and myeloid dendritic cells.
• Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis.
• Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation.
• CD32B may also be a target for monoclonal antibody therapy for malignancies.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 21.8 kDa.
• The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.