T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain.
is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.
CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2).
When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs).
The CD86 expression on antigen presenting cells is constitutive.
CD28 is the only B7 receptor constitutively expressed on naive T cells.
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 42.0 kDa.
The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human / Cynomolgus / Rhesus macaque CD28, Mouse IgG2a Fc Tag (CD8-H52A5) is expressed from human 293 cells (HEK293). It contains AA Asn 19 - Pro 152 (Accession # P10747-1). In the region Asn 19 - Pro 152, the AA sequence of Human, Cynomolgus and Rhesus macaque CD28 are homologus.
Species Reactivity：Human / Cynomolgus / Rhesus macaque
