Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ.
CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation).
CD86 works in tandem with CD80 to prime T cells.
Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival.
Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages.
CD86 thus is regarded as a promising candidate for immune therapy.
CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 27.3 kDa.
The protein migrates as 40-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus / Rhesus macaque B7-2, His Tag (MALS verified) (CD6-C52H5) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - His 240 (Accession # G7NXR4-1). In the region Ala 19 - His 240, the AA sequence of Cynomolgus and Rhesus macaque B7-2 are homologus.
