It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2.
S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.
S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
特徴
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 28.1 kDa.
The protein migrates as 33-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated SARS-CoV-2 Spike RBD (R346S, N394S, Y449N, E484K, F490S, N501Y), His,Avitag (SPD-C82Er) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (R346S, N394S, Y449N, E484K, F490S, N501Y)). The mutations (R346S, N394S, Y449N, E484K, F490S, N501Y) were identified in the SARS-CoV-2 variant (PANGO Lineage: B.1.640.2).
Species Reactivity：SARS-CoV-2
Host：HEK293
Tag：C-10×His & C-Avi
Exp Region：Arg 319 - Lys 537
Format：Powder
Conjugate：Biotin-labeled
Protein ID：QHD43416.1 (R346S, N394S, Y449N, E484K, F490S, N501Y)
