B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions.
B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function.
Recently, B7-H7 has been identified as a specific ligand for human CD28H.
The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway.
The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 63.4 kDa.
The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human B7-H7, Fc Tag (B77-H5257) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Asn 344 (Accession # Q9UM44-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Ile 23 - Asn 344
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9UM44-1
Protein ID：NP_009003.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
