B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions.
B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function.
Recently, B7-H7 has been identified as a specific ligand for human CD28H.
The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway.
The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 39.2 kDa.
The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus B7-H7, His Tag (B77-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 21 - Asn 345 (Accession # XP_005548285.1).
