ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family.
ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain.
Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen.
B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS.
B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells.
B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 53.1 kDa.
The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human B7-H2, Fc Tag (B72-H5254) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Ser 258 (Accession # O75144-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Asp 19 - Ser 258
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O75144-1
Protein ID：NP_056074.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
