83-3870-75　Biotinylated Human B7-1 / CD80 Protein, Fc,Avitag （MALS verified） 200ug　B71-H82F2-200ug

特徴

• 背景
• B7-1 and B7-2, together with their receptors CD28 and CTLA­4, constitute one of the dominant co-stimulatory pathways that regulate T­ and B­cell responses.
• Although both CTLA­4 and CD28 can bind to the same ligands, CTLA­4 binds to B7­1 and B7­2 with a 20 ­ 100 fold higher affinity than CD28 and is involved in the down­regulation of the immune response.B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells.
• It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation).
• CD80 works in tandem with CD86 to prime T cells.
• CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages.
• CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
• The protein has a calculated MW of 52.3 kDa.
• The protein migrates as 65-95 kDa under reducing (R) condition, and 130-160 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.