4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily.
CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells.
In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
The best characterized activity of CD137 is its costimulatory activity for activated T cells.
Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity.
Further, it can enhance immune activity to eliminate tumors in mice.
CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex.
In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity.
4-1BB thus is a promising candidate for immunotherapy of human cancer.
CD137 has been shown to interact with TRAF2.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 43.4 kDa.
The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Canine 4-1BB Protein, Fc Tag (41B-C5253) is expressed from human 293 cells (HEK293). It contains AA Ile 24 - Ser 185 (Accession # XP_850336.1).
Species Reactivity：Canine
Host：HEK293
Tag：C-Fc
Exp Region：Ile 24 - Ser 185
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：E2R1R9-1
Protein ID：XP_850336.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
