T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins.
CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex.
T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
特徴
Human CD3E&CD3D Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of CD3E and CD3D, has a calculated MW of 38.3 kDa (CD3E) and 35.8 kDa (CD3D).
Subunit CD3E is fused with a human IgG1 Fc tag at the C-terminus and subunit CD3D is fused with a human IgG1 Fc tag at the C-terminus.
As a result of glycosylation, the protein migrates as 45-60 kDa under reducing (R) condition, and 90-110 kDa under non-reducing (NR) condition (SDS-PAGE).
仕様
容量：100ug
Source：Human CD3E&CD3D Heterodimer Protein, Fc Tag&Fc Tag (CDD-H5255) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D) (Accession # P07766-1 (CD3E) & P04234-1 (CD3D)).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc | C-Fc
Exp Region：Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D)
