Interleukin 35 (IL-35) is a recently discovered anti-inflammatory cytokine from the IL-12 family.
Member of IL-12 family - IL-35 is produced by wide range of regulatory lymphocytes and plays a role in immune suppression.
IL-35 can block the development of Th1 and Th17 cells by limiting early T cell proliferation.
The heterodimeric cytokine of IL-35 involves two subunits of p35 and Ebi3 which are also seen in IL-12 and IL-27.
IL-35 is recognized as a defi nite immunosuppressor with a huge potent of suppression.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 73.1 kDa & 71.5 kDa.
The protein migrates as 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human IL-35 R, His Tag (ILR-H52H8) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Glu 619 & Lys 24 - Asn 622 (Accession # P40189-1(gp130) & Q99665-1(IL12Rb2)).
