It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2.
S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.
S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 34.5 kDa.
The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：SARS-CoV-2 S1 protein NTD (HV69-70del, Y144del), His Tag (S1D-C52Hd) is expressed from human 293 cells (HEK293). It contains AA Ser 13 - Leu 303 (Accession # QHD43416.1 (HV69-70del, Y144del)). The HV69-70del/Y144del mutations were identified on the spike protein N-terminal domain (NTD) in the SARS-CoV-2 Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01).
