It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2.
S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor.
S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 101.1 kDa.
The protein migrates as 125-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：SARS-CoV-2 S1 protein, Fc Tag (S1D-C5254) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685 (Accession # QHD43416.1). The mutations (HV69-70del, Y144del, N501Y, A570D, D614G, P681H) were identified in the SARS-CoV-2 Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01).
Species Reactivity：SARS-CoV-2
Host：HEK293
Tag：C-Fc
Exp Region：Val 16 - Arg 685
Format：Powder
Conjugate：Unconjugated
Protein ID：QHD43416.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 0.2 M Arginine, 150 mM NaCl, pH7.5
