CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen.
CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn.
CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency.
It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
特徴
This protein carries a llama IgG2b Fc tag at the C-terminus.
The protein has a calculated MW of 88.6 kDa.
The protein migrates as 200-250 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：This protein carries a human IgG2a Fc tag at the C-terminus. Human CD45, Llama IgG2b Fc Tag, low endotoxin (CD5-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Lys 577 (Accession # P08575-3).
Species Reactivity：Human
Host：HEK293
Tag：C-LlamaFc(LlamaIgG2b)
Exp Region：Gln 26 - Lys 577
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P08575-3
Endotoxin：0.05 EU per μg
Purity：90%
Buffer：50 mM Tris, 200 mM Glycine, 25 mM Arginine, 150mM NaCl, pH7.5
