Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V.
Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin.
It recognizes the sequence R-G-D in its ligands.
Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1.
Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes.
This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
特徴
Biotinylated Mouse ITGAV&ITGB6 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 80.2 kDa (ITGB6).
Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa and 135-150 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Mouse ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free (IT6-M82W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 22 - Pro 708 (Accession # P43406-1 & Q9Z0T9-1).
