CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein.
CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain.
CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex.
This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11.
The epsilon polypeptide plays an essential role in T-cell development.
CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency.
CD3E gene has also been linked to a susceptibility to type I diabetes in women.
CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag.
The protein has a calculated MW of 38.3 kDa.
The protein migrates as 43-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus CD3 epsilon, Fc,His Tag (CDE-C5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asp 117 (Accession # Q95LI5).
Species Reactivity：Cynomolgus
Host：HEK293
Tag：C-Fc & C-6×His
Exp Region：Gln 22 - Asp 117
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q95LI5
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
