Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus.
Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA.
Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs).
Angiogenin induces vascularization of normal and malignant tissues.
Angiogenic activity is regulated by interaction with RNH1 in vivo
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 16.0 kDa.
The protein migrates as 12 kDa and 17-18 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human Angiogenin, His Tag (ANN-H5149) is expressed from E. coli cells. It contains AA Gln 25 - Pro 147 (Accession # P03950-1).
