Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily.
GHR contains one fibronectin type-III domain.
GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle.
The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE.
GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth.
On ligand binding, couples to the JAK2/STAT5 pathway.
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 30.2 kDa.
The protein migrates as 36-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Rat Growth Hormone R, His Tag (GHR-R52H8) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 265 (Accession # P16310-1).
