Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation.
IL‑17C binds to IL‑17 RE with high affinity and to IL‑17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE.
Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways.
Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G.
Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 21.7 kDa.
The protein migrates as 25-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse IL-17C, His Tag (ILC-M52H7) is expressed from human 293 cells (HEK293). It contains AA Asp 17 - Gln 194 (Accession # Q8K4C5-1).
