The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence.
KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells.
Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 17.4 kDa.
The protein migrates as 30-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human KLRG1, His Tag (KL1-H5249) is expressed from human 293 cells (HEK293). It contains AA Leu 60 - Phe 195 (Accession # Q96E93-1).
