Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells.
Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells.
CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation.
CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses.
CD70 induces proliferation and IFNγ production, on NK cells.
特徴
This protein carries a mouse IgG2a Fc tag at the N-terminus.
The protein has a calculated MW of 44.0 kDa.
The protein migrates as 50-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human CD27 Ligand Protein, Mouse IgG2a Fc Tag (CDL-H525a) is expressed from human 293 cells (HEK293). It contains AA Gln 39 - Pro 193 (Accession # P32970-1).
Species Reactivity：Human
Host：HEK293
Tag：N-mFc(mIgG2a)
Exp Region：Gln 39 - Pro 193
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P32970-1
Protein ID：NP_001243.1
Endotoxin：0.1 EU per μg
Purity：85%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
