Human Plasma Kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma by binding to high molecular weight (HMW) kininogen or as a free zymogen.
The enzyme cleaves Lys-Arg and Arg-Ser bonds.
It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface.
It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 71.1 kDa.
The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：500ug
Source：Human Plasma Kallikrein/KLKB1, His Tag (KL1-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ala 638 (Accession # P03952-1).
