CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen.
CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn.
CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency.
It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 53.2 kDa.
The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human CD45RA / PTPRC protein, His Tag (CD5-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Lys 482 (Accession # P08575-8).
