Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1).
Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS).
It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition.
GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk.
Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes.
Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 14.6 kDa.
The protein migrates as 16-17 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Mouse GDF-15, His Tag (GD5-M5149) is expressed from E. coli cells. It contains AA Ser 189 - Ala 303 (Accession # Q9Z0J7-1).
