83-3863-45　Mouse Complement C3 Protein, His Tag （MALS verified） 1mg　CO3-M52H4-1mg

特徴

• 背景
• C3 is the major complement component serum.
• It is mainly synthesized by macrophages and liver.
• C3 plays a central role in the activation of the complement system.
• Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways.
• It is cleaved into two fragments, C3a and C3b.
• C3a anaphylatoxin is a mediator of local inflammatory process.
• In chronic inflammation, acts as a chemoattractant for neutrophils.
• After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
• It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 186.1 kDa.
• The protein migrates as 70 kDa, 100-120 kDa and 160-180 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.