Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions.
There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
特徴
This protein carries no "tag".
The protein has a calculated MW of 8.4 kDa.
The protein migrates as 11 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Cynomolgus Complement C5a, Tag Free (C5A-C5118) is expressed from E. coli cells. It contains AA Met 678 - Arg 751 (Accession # XP_015292262.1).
