Laminin-221 (LM221) takes multiple roles as a scaffold to store cells, growth factors and cytokines and is the most likely expressed cardiac laminin that maintains physiological activities of myocytes.
Laminin 221-E8 consists of the C-terminal end of the alpha 2, beta 2, and gamma 1 chains.
Previous study has confirmed that the laminin-221 heterotrimer (α2β2γ1) could bind integrin α7X1 and α7X2.
Latest research indicated that the administration of LM221 enhanced accumulation of smooth muscle actin (SMA) and isolectin B4 (ILB4) double-positive cells to the damaged area and contributed to the improvement of cardiac function.
特徴
Human Laminin 221 Protein, premium grade, produced by co-expression of Laminin alpha2E8, Laminin beta2E8 and Laminin gamma1E8, has a calculated MW of 94.3 kDa, 51.3 kDa and 53.7 kDa.
The non-reducing (NR) protein migrates as 118-133 kDa due to glycosylation.
仕様
容量：100ug
Source：Human Laminin 221 Protein, premium grade (LA2-H5269) is expressed from human 293 cells (HEK293). It contains AA Leu 1900 - Ala 2722 (Laminin alpha2E8) & Leu 1573 - Gln 1798 (Laminin beta2E8) & Asn1364 - Pro1609 (Laminin gamma1E8) (Accession # P24043-1 (Laminin alpha2E8) & P55268-1 (Laminin beta2E8) & P11047-1 (Laminin gamma1E8)).
