Discoidin domain receptor 1 (DDR1) is a member of DDRs, which are members of the receptor tyrosine kinase (RTK).
Upon collagen binding, DDR1 undergoes tyrosine autophosphorylation, which consequently triggers downstream genetic and cellular pathways and plays critical roles in the regulation of cellular morphogenesis, differentiation, proliferation, adhesion, migration, and invasion.
Research shows that DDR1 is closely related to various human diseases including cancer, fibrosis, atherosclerosis, and other inflammatory disorders.
New generation DDR1 inhibitors targeting the allosteric sites outside of the canonical ATP-binding pocket or extracellular domain (allosteric inhibitors) may offer a new opportunity for selective DDR1 inhibition therapy development.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 70.2 kDa.
The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse DDR1, Fc Tag (DD1-M5259) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Thr 414 (Accession # Q03146-1).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Asp 22 - Thr 414
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q03146-1
Protein ID：NP_766550.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl,pH7.5
