IL-28 R alpha (Interleukin-28 receptor subunit alpha) also known as IFNLR1 (IFN-lambda receptor 1), it heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor ,which binds IL-28A, IL-28B and IL-29.
These ligands, which are distantly related to class I in terferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity.
The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Determines the cell type specificity of the lambda interferon action.
Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 25.5 kDa.
The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human IL-28 R alpha, His Tag (ILR-H52H9) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Ala 228 (Accession # Q8IU57-1).
