Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds.
Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport).
IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
特徴
This protein carries an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tag.
The protein has a calculated MW of 28.8 kDa.
The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human IgG1 Fc (C103S), Avitag,His Tag (IG1-H82E9) is expressed from human 293 cells (HEK293). It contains AA Pro 100 - Lys 330 (Accession # P01857-1 (C103S)).
Species Reactivity：Human
Host：HEK293
Tag：C-Avi & C-6×His
Exp Region：Pro 100 - Lys 330
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：P01857-1 (C103S)
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
