LAMPs (lysosome associated membrane proteins) represent a family of glycosylated proteins present predominantly on the membrane of lysosomes whose expression can vary among different tissues, suggesting a separation of functions.
LAMP5 is expressed highly and specifically in MLL-r leukemia.
LAMP5 is a direct target of the oncogenic MLL-fusion protein.
LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo.
Functional studies showed that LAMP-5 is a novel modulator of innateimmune pathways in MLL-r leukemias.
Downregulation of LAMP5 led to inhibition of NF-κB signaling and increased activation of type-1 interferon signaling downstream of Toll-like Receptor/Interleukin 1 Receptor activation.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 25 kDa.
The protein migrates as 31-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human LAMP5, His Tag (LA5-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 30 - Glu 235 (Accession # Q9UJQ1-1).
