83-3862-33　Mouse CD3 epsilon Protein, Fc Tag 1mg　CDE-M5256-1mg

特徴

• 背景
• CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein.
• CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain.
• CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex.
• This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
• The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11.
• The epsilon polypeptide plays an essential role in T-cell development.
• CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency.
• CD3E gene has also been linked to a susceptibility to type I diabetes in women.
• CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus.
• The protein has a calculated MW of 36 kDa.
• The protein migrates as 40-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.