Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis.
It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7).
Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1).
Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 62.6 kDa.
The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human BST1, His Tag (ENN-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 26 - Gly 586 (Accession # P17813-1).
