Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells).
In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor.
The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13.
STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine.
Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 41.4 kDa.
The protein migrates as 46-50 kDa and 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus IL-4, Fc Tag (IL4-C5259) is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # P79339-1).
Species Reactivity：Cynomolgus
Host：HEK293
Tag：C-Fc
Exp Region：His 25 - Ser 153
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P79339-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
