CXCL4, or Platelet factor 4 (PF4), is a small cytokine belonging to the CXC chemokine family.
This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation.
CXCL4 is chemotactic for neutrophils and monocytes and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
CXCL4/PF4 is up-regulated in human liver fibrosis and that it plays a nonredundant, functional role in experimental liver fibrosis by mediating stellate cell proliferation, migration, and intrahepatic immune cell recruitment.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 9.7 kDa.
The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human CXCL4, His Tag (CX4-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 32 - Ser 101 (Accession # P02776-1).
