CD131- the common β Subunit, is a member of the type 1 cytokinereceptor family.
There are three major classes of heteroreceptor complexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit.
These three classes include those which use gp130, those which use γc and those which use the common β subunit, βc(CD131).
CD131 is shared by three of the “four-helical bundle” family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific α chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific α subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 75.1 kDa.
The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human CD131, Fc Tag (CD1-H5256) is expressed from human 293 cells (HEK293). It contains AA Trp 17 - Trp 443 (Accession # P32927-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Trp 17 - Trp 443
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P32927-1
Protein ID：NP_000386.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
