CCL3, also know as MIP-1-alpha, is monokine with inflammatory and chemokinetic properties.
CCL3 is an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies.
Binds to CCR1, CCR4 and CCR5.
One of the major HIV-suppressive factors produced by CD8+ T-cells.
Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 9.7 kDa.
The protein migrates as 12-13 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：20ug
Source：Human CCL3, His Tag (CC3-H5249) is expressed from E. coli cells. It contains AA Ser 24 - Ala 92 (Accession # P10147-1).
Species Reactivity：Human
Host：E. coli
Tag：N-10×His
Exp Region：Ser 24 - Ala 92
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P10147-1
Protein ID：NP_002974.1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：20 mM Tris,150 mM NaCl,0.2 M Arginine,1 mM EDTA,pH8.0
