Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family.
SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways.
Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4.
Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 39.0 kDa.
The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human SIGIRR, Fc Tag (SIR-H5255) is expressed from human 293 cells (HEK293). It contains AA Met 1 - His 118 (Accession # Q6IA17-1).
