GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128.
Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease.
GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15.
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses .
Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 64.2 kDa.
The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human GFR alpha-like, Fc Tag (GFE-H5259) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Glu 351 (Accession # Q6UXV0-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Ser 19 - Glu 351
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q6UXV0-1
Protein ID：NP_997293.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
